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Tobias Gerhard’s et al article, “Comparative Mortality Risks of Antipsychotic Medications in Community-Dwelling Older Adults” in British Journal of Psychiatry Receives Notable Editorial by Clive Ballard (and colleagues)

Tobias Gerhard et al clarify our understanding of mortality associated with antipsychotic use in people with dementia by demonstrating a clear dose relationship and highlighting key questions regarding the relative mortality risk of different atypical antipsychotics. The study is the first to carefully examine the relationship between antipsychotic dose and mortality risk, showing a clear stepwise increase in risk from low to medium and from medium to high doses. This is potentially extremely important in guiding clinical practice, although it is still important that treatments are prescribed within the therapeutic window shown to be effective. The study also suggests that antipsychotics may confer risks of increased mortality in older people without dementia.

Clive Ballard, Anne Corbett and Robert Howard, “Prescription of Antipsychotics in People with Dementia.” British Journal of Psychiatry, 2014: 205:4-5.

T. Gerhard, K. Huybrechts, M. Olfson, S. Schneeweiss, W. V. Bobo, P. M. Doraiswamy, D. P. Devanand, J. A. Lucas, C. Huang, E. S. Malka, R. Levin and S. Crystal, “Comparative Mortality Risks of Antipsychotic Medications in Community-dwelling Older Adults.” British Journal of Psychiatry, 2014: 205:44-51.

You can read the articles here.

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